What question did this study set out to answer?

This research aims to explore the efficacy of bacteriophages PES-1 and PES-2 against drug-resistant ETEC and their potential as biocontrol agents.

Characterization and phage-antibiotic synergy of bacteriophages PES-1 and PES-2 against porcine enterotoxigenic Escherichia coli

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Randomized trial demonstrates enhanced antibacterial efficacy of bacteriophages in ETEC, indicating potential biocontrol solutions.

This research aims to explore the efficacy of bacteriophages PES-1 and PES-2 against drug-resistant ETEC and their potential as biocontrol agents.
Isolated and characterized lytic bacteriophages PES-1 and PES-2 against ETEC strains.
Conducted genomic analysis of both phages, detailing their characteristics and stability ranges.
Evaluated synergy with antibiotics, notably amoxicillin and neomycin, comparing efficacy against bacterial loads.
PES-1 lysed five ETEC strains, while PES-2 affected only one strain, demonstrating a wide host range versus restricted specificity.
Combination with amoxicillin showed a decrease in bacterial loads by 2.02–3.47 log units (p < 0.05) compared to amoxicillin alone.
No significant difference was noted in the gentamycin-phage combination compared to the phage cocktail.

Li et al. (2026) studied this question.

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