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September 13, 2024

Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure

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Authors

YOYoshiki OhnukiKSKenji SuitaMIMisao Ishikawa

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Cite This Study

Ohnuki et al. (2024) studied this question.

synapsesocial.com/papers/68e58a5ab6db6435875262e8https://doi.org/10.21203/rs.3.rs-4868106/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure2025
  2. 2Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses2014 · 142 citations
  3. 3The cAMP binding protein Epac regulates cardiac myofilament function2009 · 85 citations
  4. 4Depotentiation of intact rat cardiac muscle unmasks an Epac‐dependent increase in myofilament Ca<sup>2+</sup> sensitivity2015 · 13 citations
  5. 5Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca <sup>2+</sup> Leak and Arrhythmia2013 · 188 citations