September 12, 2024EurosurveillanceOpen Access

Relative effectiveness of bivalent boosters against severe COVID-19 outcomes among people aged ≥ 65 years in Finland, September 2022 to August 2023

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Register-based cohort study demonstrates bivalent boosters halve severe COVID-19 risks in older adults, highlighting waning protection over time.

Severe COVID-19 hospitalisations and deaths dropped by roughly half after bivalent boosters, but protective benefits waned over subsequent months.
A hazard ratio of 0.45 demonstrated reduced COVID-19 hospitalisation risk among booster recipients, while the hazard ratio for death was 0.49.
Register-based cohort analysis evaluated 1,191,871 older individuals with Cox regression, highlighting that waning immunity calls for updated boosters.

Poukka et al. (2024) studied this question.

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Register-based cohort study demonstrates bivalent boosters halve severe COVID-19 risks in older adults, highlighting waning protection over time.