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September 12, 2024Frontiers in ImmunologyOpen Access

Immune responses and transcription landscape of adults with the third dose of homologous and heterologous booster vaccines of COVID-19

Hui Zheng Cuidan Li Xiuyu Zheng Hu-Dachuan Jiang Yuqing Li Aihua Yao Xiaolong Li Feiyu Wang Wenqing Liu Xiang Cao Runjie Qi Li Chen Lairun Jin Fengcai Zhu Jingxin Li Fei Chen

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Abstract

Heterologous booster vaccines are more effective than homologous booster vaccines in combating the coronavirus disease 2019 (COVID-19) outbreak. However, our understanding of homologous and heterologous booster vaccines for COVID-19 remains limited.

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Cite This Study

Zheng et al. (2024) studied this question.

synapsesocial.com/papers/68e58b97b6db643587526f2a https://doi.org/10.3389/fimmu.2024.1461419

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency2024 · 11 citations
2Homologous but not heterologous COVID-19 vaccine booster elicits IgG4+ B-cells and enhanced Omicron subvariant binding2024 · 18 citations
3T and B cell responses in different immunization scenarios for COVID-19: a narrative reviewLiterature Review · 2025 · 13 citations
4Systemic immune profiling of heterologous versus homologous boosting of COVID-19 vaccinationOriginal Research · 2026
5Antibody Response after Homologous and Heterologous Prime–Boost COVID-19 Vaccination in a Bangladeshi Residential University Cohort2024 · 3 citations

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Relative effectiveness of a heterologous booster dose with adenovirus type 5 vectored COVID-19 vaccine versus three doses of inactivated COVID-19 vaccine in adults during a nationwide outbreak of omicron predominance, in China: a retrospective, individually matched cohort-control study2024
Longevity and Magnitude of Antibody Responses After Homologous and Heterologous COVID-19 Booster Vaccinations in Bangladesh2026

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