What question did this study set out to answer?

This study aims to evaluate the magnitude and durability of SARS-CoV-2-specific IgG antibody responses after different COVID-19 booster vaccinations.

June 17, 2026VaccinesOpen Access

Longevity and Magnitude of Antibody Responses After Homologous and Heterologous COVID-19 Booster Vaccinations in Bangladesh

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Authors

MAMarjahan AkhtarInternational Centre for Diarrhoeal Disease Research MIMd. Rashedul IslamUniversity of Dhaka ZKZahid Hasan KhanInternational Centre for Diarrhoeal Disease Research

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Implication

Randomized trial evaluates antibody responses from different COVID-19 vaccine boost strategies, suggesting implications for effective vaccination planning.

Key Points

This study aims to evaluate the magnitude and durability of SARS-CoV-2-specific IgG antibody responses after different COVID-19 booster vaccinations.
Enrolled 6300 adults from nine hospitals across eight divisions of Bangladesh.
Participants received two primary doses of various vaccines and booster doses at one-year intervals.
Measured IgG antibody responses using ELISA at multiple time points post-vaccination.
Higher IgG levels observed with heterologous mRNA boosters compared to homologous boosters for those initially vaccinated with adenovirus or inactivated vaccines.
Only 5.5% received a second booster one year after the first, with 99% receiving the BNT162b2 vaccine.
Significant decline in IgG levels after the second booster dose compared to sustained levels after the first booster.

Cite This Study

Akhtar et al. (2026) studied this question.

synapsesocial.com/papers/6a323d23d50b63ecad206f3f https://doi.org/10.3390/vaccines14060531

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Implication

Randomized trial evaluates antibody responses from different COVID-19 vaccine boost strategies, suggesting implications for effective vaccination planning.

Longevity and Magnitude of Antibody Responses After Homologous and Heterologous COVID-19 Booster Vaccinations in Bangladesh

Discussion

Member takes

Implication

Key Points

Cite This Study

Longevity and Magnitude of Antibody Responses After Homologous and Heterologous COVID-19 Booster Vaccinations in Bangladesh

Discussion

Member takes

Implication

Key Points

Cite This Study

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