Laboratory study demonstrates misdirected placental trophoblast lineage specification during Toxoplasma gondii infection, indicating disrupted fetal developmental defenses.
Pregnancy is a critical point of vulnerability to infection and other insults that could compromise proper fetal development. The placenta acts as a protective and nutrient-permeable barrier to most infectious agents, but a few are capable of bypassing its defenses. Remarkably little is known about how exposure to these select pathogens might impact ongoing placental development. Here we demonstrate that
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