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September 11, 2024Frontiers in ImmunologyOpen Access

CD8 T cells promote heart failure progression in mice with preexisting left ventricular dysfunction

Dongzhi Wang Xinyu Weng Wenhui Yue Linlin Shang Yidong Wei John S. Clemmer Yawei Xu Yingjie Chen

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Abstract

Even under the standard medical care, patients with left ventricular (LV) failure or heart failure (HF) often progress to pulmonary hypertension and right ventricular (RV) hypertrophy. We previously showed that inflammation and regulatory T cells (Tregs) modulate HF progression in mice with preexisting LV failure. The main objective of this study is to determine the role of CD8

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Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e58cbfb6db643587528415 https://doi.org/10.3389/fimmu.2024.1472133

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1CD8 T cells exert a critical role in the transition from left heart failure to lung remodeling and right ventricular hypertrophy2024
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