September 11, 2024AJP Endocrinology and Metabolism

Contractile regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle

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Muscle contractions counter glucocorticoid-induced transcriptomic alterations in aged skeletal muscle, blunting signaling pathways tied to muscle atrophy and inflammation.
Dosing of 2 mg/kg dexamethasone provoked similar gene changes across cohorts, but contractions opposed more glucocorticoid-sensitive transcripts in aged tissue.
RNA sequencing of contracting tibialis anterior muscle supports targeting pparg, though results reflect a mouse model needing clinical validation.

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Implication

Randomized trial reveals muscle contractions counter glucocorticoid-driven transcriptomic shifts in aged mice, suggesting exercise-induced pathways can mitigate atrophy.

Cite This Study

Laskin et al. (2024) studied this question.

synapsesocial.com/papers/68e58cc8b6db6435875288e5 https://doi.org/10.1152/ajpendo.00223.2024

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Implication

Randomized trial reveals muscle contractions counter glucocorticoid-driven transcriptomic shifts in aged mice, suggesting exercise-induced pathways can mitigate atrophy.

Contractile regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle

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Discussion

Implication

Cite This Study

Contractile regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle

Key Points

Discussion

Implication

Cite This Study

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