Biological Activity of Streptomyces sp. Isolated from Soil in the Municipality of Pinheiro-MA

Objective: To evaluate the antibacterial activity of secondary metabolites produced by Streptomyces sp. isolated from soil contaminated by solid waste, against resistant microorganisms. Method: For this, soil samples were collected, isolation, micro and macro morphological identification and removal of secondary metabolites (ethyl acetate) were carried out. After obtaining the metabolites, the agar diffusion test was carried out and the Minimum Inhibitory Concentration (MIC) was assessed. Results and Discussion: Streptomyces sp. was isolated, which presented an inhibition halo for the pathogens tested, with an average halo for Pseudomonas aeruginosa ATCC 27853 of 21.67±0 mm; for the lineages of clinical isolates from the nasopharynx, such as Corynebacterium propinquum 431024 and 36063E, they presented halos of 20±0 mm and 23.3±2.9 mm respectively. Regarding the MIC test, inhibition results were observed for P. aeruginosa ATCC 27853 (500 µg/mL), C. propinquum 431024 (7.8µg/mL) and C. propinquum 36063E (7.8µg/mL). Conclusion: Therefore, the isolate of the genus Streptomyces sp. demonstrated antibacterial action against pathogens of clinical interest and may be the target of new discoveries in the control and resistance of these pathogens. Originality/Value: The importance of this study is highlighted by the urgent demand for new antibiotics, especially given the growing antimicrobial resistance around the world. Furthermore, this research highlights the potential for bioprospecting in contaminated soils, suggesting that the management and recovery of these environments can become innovative sources of pharmacological development.