Giant melanocytic nevoid lesions, over 20 cm in diameter, are referred to as ‘bathing trunk nevi’ or ‘giant congenital melanocytic nevus (CMN)’, and have an incidence of 1 in 2,00,000 to 1 in 5,00,000 neonates. Diffuse lipomatosis, von-Recklinghausen’s disease, neurocutaneous melanosis and malignant melanoma are a few serious pathologies that are sometimes linked to these lesions. They begin as dark brown to black patches with a smooth or rugose surface, hair-covered, clearly defined boundaries and frequently associated sporadic satellite lesions. Between the 5th and 25th week of pregnancy, melanocytes of neuroectodermal origin may accumulate ectopically and cause these lesions. A multitude of histological elements, such as neuronal, lipomatous or any other, may be linked to giant CMN. The fact that these lesions are a progeny of pluripotent stem cells, which have the ability to develop into a variety of cell types, justifies this finding. Patients and their families have severe aesthetic and psychological concerns about these enormous pigmented nevi.
No takes yet. Share an insight, caveat, or question.
Sushantika Sushantika (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: