Key result
Lp(a) >100 mg/dL is linked to higher risk for severe degenerative aortic stenosis and replacement.
Why the study?
Lipoprotein(a) is associated with aortic valve calcification, but its relationship with severe degenerative aortic stenosis and aortic valve replacement is unclear.
Is elevated serum Lp(a) >100 mg/dL associated with the development of severe degenerative aortic stenosis and subsequent aortic valve replacement?
Cohort (n=44,742)
No
Is elevated serum Lp(a) >100 mg/dL associated with the development of severe degenerative aortic stenosis and subsequent aortic valve replacement?
Answers are grounded in this paper and cite their sources.
Elevated Lp(a) levels >100 mg/dL are significantly associated with the progression to severe degenerative aortic stenosis and the need for aortic valve replacement.
Background: Lipoprotein(a) (Lp[a]) is associated with the development of aortic valve calcification. Objectives: The aim of this study was to evaluate the association between the serum level of Lp(a) and the development of severe degenerative aortic stenosis (AS) and subsequent aortic valve replacement (AVR). Methods: A total of 44,742 patients with Lp(a) measurements and echocardiography at baseline evaluation between 2000 and 2020 were included from a single tertiary heart center. The primary outcome was the development of severe degenerative AS, defined as a transaortic maximal velocity of ≥4.0 m/s. Conclusions: Lp(a) levels >100 mg/dL were significantly associated with risk for severe degenerative AS and subsequent AVR, regardless of the baseline severity of AS. Such associations were not observed in other etiologies of severe AS.
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Kim et al. (2024) conducted a cohort in Degenerative aortic valve stenosis (n=44,742). Lipoprotein(a) levels >100 mg/dL vs. Lower Lipoprotein(a) levels was evaluated on Development of severe degenerative AS, defined as a transaortic maximal velocity of ≥4.0 m/s. Lipoprotein(a) levels >100 mg/dL were significantly associated with risk for severe degenerative aortic stenosis and subsequent aortic valve replacement.
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