Identifying People at High Risk for Severe Aortic Stenosis: Aortic Valve Calcium Versus Lipoprotein(a) and Low-Density Lipoprotein Cholesterol

Natalie Marrero; Kunal Jha; Alexander C. Razavi; Ellen Boakye; Khalil Anchouche; Omar Dzaye; Matthew J. Budoff; Michael Y. Tsai; Sanjiv J. Shah; Jerome I. Rotter; Xiuqing Guo; Jie Yao; Roger S. Blumenthal; George Thanassoulis; Wendy S. Post; Michael J. Blaha; Seamus P. Whelton

doi:10.1161/circimaging.123.016372

June 1, 2024Circulation Cardiovascular Imaging

Identifying People at High Risk for Severe Aortic Stenosis: Aortic Valve Calcium Versus Lipoprotein(a) and Low-Density Lipoprotein Cholesterol

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Key Points

Severe aortic stenosis is linked to aortic valve calcification along with circulating lipoprotein a and elevated low-density lipoprotein cholesterol levels.
Comparative risk assessment evaluates which vascular biomarkers demonstrate the strongest association with the onset of incident severe aortic stenosis.
Differentiating aortic valve calcium from atherogenic lipoproteins supports improved clinical screening and may guide targeted preventative interventions.

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Abstract

Aortic valve calcification (AVC), Lp(a) [lipoprotein(a)], and low-density lipoprotein cholesterol (LDL-C) are associated with severe aortic stenosis (AS). We aimed to determine which of these risk factors were most strongly associated with the risk of incident severe AS.

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Marrero et al. (2024) studied this question.

synapsesocial.com/papers/68e66b13b6db6435875f6316 https://doi.org/10.1161/circimaging.123.016372

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Identifying People at High Risk for Severe Aortic Stenosis: Aortic Valve Calcium Versus Lipoprotein(a) and Low-Density Lipoprotein Cholesterol

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Identifying People at High Risk for Severe Aortic Stenosis: Aortic Valve Calcium Versus Lipoprotein(a) and Low-Density Lipoprotein Cholesterol

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

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