The role of magnesium deficiency control in recovery after treatment for oncogynecological diseases

Background. Magnesium is one of the main macronutrients involved in maintaining human health. Magnesium deficiency (DM) is a common problem in patients after radical cancer therapy, including women with malignant neoplasms of reproductive system. To date, no large-scale studies have been conducted on the prevalence of DM in the convalescence period after oncogynecological treatment. Objective : clinical assessment of DM in patients during rehabilitation period after treatment for reproductive system cancer. Material and methods . The study consisted of two stages. At the first stage (cross-sectional study), 9,168 women with hormonedependent conditions (endometriosis and hyperplastic endometrial processes, uterine fibroids, polycystic ovary syndrome) aged 18–60 years were selected. The second stage (longitudinal study) included 2,101 women with confirmed DM who took a combination of magnesium citrate and pyridoxine. The dynamics of changes were assessed after 1 month using Magnesium Deficiency Questionnaire (MDQ) and World Health Organization Quality of Life Brief Version (WHOQOL-BREF) questionnaire. Results . We analyzed information on 70 (0.76%) patients who were in the recovery period after treatment for malignant neoplasms of female reproductive system. According to MDQ data, 57.1% of women had a high risk of MD, 37.1% had an average risk, and 5.7% had no MD. According to biochemical blood test, MD was found in 76.9% of patients. One month after the appointment of magnesium preparations, high probability of DM according to MDQ decreased to 16.7%, and the average risk was 66.7%. The absence of MD was determined in 16.7% of women. MD was found in blood plasma in 33.3% of cases. In the study group, a decrease in the prevalence of seizures, nervousness, muscle weakness was determined. Analyzis of results by WHOQOL-BREF confirmed an improvement in the quality of life of patients (physical and psychological condition and environment). Conclusion. The results substantiate the importance of DM early detection and correction in women who are in the rehabilitation period after treatment of reproductive organs. Increasing the alertness of doctors, conducting dynamic monitoring of magnesium content will accelerate the diagnosis, which is necessary to prevent the development of DM-related complications and increase the patients’ quality of life.