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September 10, 2024MoleculesOpen Access

Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes

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Authors

SJShengzhou JinLWLanfen WangYJYing‐Gang Jia

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Overview

Experimental study reveals nickel-catalyzed carboacylation in alkenes, highlighting an efficient pathway to synthesize functionalized ketones.

Key Points

  • Three-component carboacylation of alkenes enables efficient assembly of functionalized ketones, coupling readily with secondary and tertiary alkyl bromides.
  • Transition metal catalysis establishes a modular cascade reaction, facilitating broad substrate applicability across diverse and sensitive functional groups.
  • Supports expanded access to biologically active ketones while overcoming traditional functional group incompatibility in complex organic synthesis workflows.

Cite This Study

Jin et al. (2024) studied this question.

synapsesocial.com/papers/68e58eceb6db64358752a16ehttps://doi.org/10.3390/molecules29184295
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