Figure 3 from Netrin-1 and UNC5B Cooperate with Integrins to Mediate YAP-Driven Cytostasis

YAP induces Netrin and UNC5 family members in YAPoff cancers. A–F, UNC5B Western blots from YAPoff cells ectopically expressing YAP or YAP mutants (A, C, E, F) or a TEAD4 DNA-binding-domain (DBD)-VP64 fusion protein or controls (B, D). Cell lines and tumor types are indicated in each. n = 3. G, UNC5B Western blot from YAPoff and YAPon cell lines. n = 2. H, Heatmap showing the effect of ectopic YAP on the expression of UNC5A-D or Netrins (NTN1, 2 and 4) in YAPoff cells. * FDR < 0.05; N = not detected. RNA expression levels mined from RNA-Seq data in (1).