,,What is the impact of obesity-related comorbidities on the risk of premature ageing:cross-sectional study”

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Abstract Background The relationships among aging, chronic diseases, and obesity remain complex and poorly understood. This study aimed to investigate the impact of comorbidities on premature aging in individuals with severe obesity. Methods This cross-sectional study included 99 patients with severe obesity (SG) and 30 healthy volunteers (HC). SG was further divided into subgroups based on comorbidity status. Various markers of biological aging, including interleukin-6 (IL-6), C-reactive protein (CRP), telomere length (TL), attention speed, executive functions and metabolic age, were evaluated. Results Both subgroups of patients with obesity presented elevated levels of IL-6 and CRP, shorter TLs, lower outcomes in executive functioning tests and greater metabolic age than healthy subjects. However, no significant differences were observed between patients with obesity with and without comorbidities. This study highlighted the impact of BMI on increased inflammation and revealed that hypertension and inflammation are associated with cognitive decline. Conclusions These findings suggest that obesity, regardless of comorbidities, contributes to premature aging. The presence of hypertension was linked to cognitive function decline, emphasizing the multifaceted implications of obesity for the aging process. Level of Evidence: Level III, well-designed cross-sectional study.