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Heterohelicenes continue to attract interest for their potential applications as organic chiral materials. To keep up with the demand for novel heterohelicene structures, expedient and scaleable synthetic procedures are required. We report a ‘Mallory’ photocyclisation methodology in continuous flow for the synthesis of thia-, oxa- and azahelicenes. This procedure has been sucessfully scaled-up to 9.8 mmol and can be applied to an iterative modular synthesis.
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Lyon et al. (2024) studied this question.
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