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September 8, 2024

Altered cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activation

Michael Momoh Sudiksha Rathan-Kumar Andreanna Burman Monica E Brown Francisca Adeniran Cynthia De la Garza‐Ramos James R. Goldenring Joseph T. Roland Izumi Kaji

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Abstract

Functional loss of the motor protein, Myosin Vb (MYO5B), induces various defects in intestinal epithelial function and causes a congenital diarrheal disorder, microvillus inclusion disease (MVID). Utilizing the MVID model mice,

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Momoh et al. (2024) studied this question.

synapsesocial.com/papers/68e591f9b6db64358752ce17 https://doi.org/10.1101/2024.09.03.610579

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Myosin VB is critical for progenitor cell identity and function in the intestineOriginal Research · 2026
2Distinct Treatment Outcomes between MVID Patient-Modeled Mice Suggest Epithelial Cell Maturation Is Influenced by MYO5B Functional State2024
3Microvillus inclusion disease-causing MYO5B point mutations exert differential effects on motor functionpreclinical · 2025 · 2 citations
4Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell modelpreclinical · 2010 · 135 citations
5Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatmentpreclinical · 2014 · 40 citations