⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

September 6, 2024Frontiers in Molecular BiosciencesOpen Access

A potential allosteric inhibitor of SARS-CoV-2 main protease (Mpro) identified through metastable state analysis

Asma Fatima Anupriya M. Geethakumari Wesam S. Ahmed Kabir H. Biswas

View Full Paper

Ask AI

Bookmark

Share

Abstract

Anti-COVID19 drugs, such as nirmatrelvir, have been developed targeting the SARS-CoV-2 main protease, M

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Fatima et al. (2024) studied this question.

synapsesocial.com/papers/68e59206b6db64358752d9a0 https://doi.org/10.3389/fmolb.2024.1451280

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

113b-K and Nirmatrelvir Resistance Mutations of SARS-CoV-2 Main Protease: Structural, Biochemical, and Biophysical Characterization of Free Enzymes and Inhibitor Complexes2025
2New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors2024 · 16 citations
3Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant VariantsOriginal Research · 2024 · 8 citations
4From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main ProteaseOriginal Research · 2026
5Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir2024 · 85 citations

More related papers

A comprehensive study of SARS-CoV-2 mfigain protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system2024
Design of novel and highly selective SARS-CoV-2 main protease inhibitors2024
Discovery of potential inhibitors targeting SARS-CoV-2 Mpro.2024

More from Frontiers in Molecular Biosciences

A combined computational and experimental study of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIPTue,
Deciphering isonicotinylation and mast cell-associated pathogenic patterns in Duchenne muscular dystrophy: evidence from ensemble learning-driven multi-omics and in vitro validationTue,