"Unveiling the Unforeseen: Diclofenac-Triggered Near-Fatal rapid onset Asthma in a Stable Asthmatic Individual Managed by NIV" A Unique Case report.

Abstract This case report details a 35-year-old woman with a history of mild intermittent asthma, who presented with rapid-onset severe respiratory distress shortly after ingesting oral diclofenac sodium for neck pain. Despite being well-controlled with inhalers for over a year, she developed near-fatal asthma, characterized by severe hypoxia, hypercapnia, and altered mental status, requiring immediate, multidisciplinary interventions. The patient was treated with high-flow oxygen, back-to-back nebulizations, and non-invasive ventilation (BiPAP), resulting in significant clinical improvement. This case highlights the rare but severe risk of NSAID-induced asthma exacerbations and signifies the importance of prompt recognition and aggressive treatment in managing life-threatening asthma episodes.