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This case report aims to highlight the ventilatory management challenges associated with severe asthma exacerbations complicated by barotrauma.

C52-13 Severe Asthma Exacerbation Complicated by Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax: A Case Report Highlighting Ventilatory Challenges

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This case report aims to highlight the ventilatory management challenges associated with severe asthma exacerbations complicated by barotrauma.
Described a case of a 23-year-old female with severe asthma exacerbation requiring intubation and advanced ventilatory support.
Utilized non-invasive ventilation, intubation, sedation, and eventually ECMO in response to complications including pneumothorax and cardiac arrest.
Monitored arterial blood gases for respiratory status and ventilatory synchrony throughout the clinical course.
Patient experienced pneumothorax and subcutaneous emphysema leading to intubation and worsening acidosis (pH 7.11, pCO2 77).
Developed ventilator dyssynchrony with peak pressures of 70-80 cm H2O despite sedation and lung-protective strategies.
Successfully extubated and discharged following tracheostomy and management of complications including tension pneumothorax.

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Case report demonstrates ventilatory challenges in severe asthma exacerbation with unique complications, suggesting new management strategies.

Mohamed et al. (2026) studied this question.

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Case report demonstrates ventilatory challenges in severe asthma exacerbation with unique complications, suggesting new management strategies.