Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 6, 2024Laboratory Medicine

The effect of plerixafor on autologous stem cell mobilization, cell viability, and apheresis challenges

View Full Paper
Ask AI
Bookmark
Share

Authors

CPChristian J PuzoPLPhilippa LiCTChristopher A. Tormey

Discussion

Loading...

Member takes

Overview

Retrospective chart review reports that plerixafor effectively supports stem cell collection across blood cancers, suggesting lower target achievement reflects its selective use in poor mobilizers.

Key Points

  • Hematopoietic stem cell mobilization goal attainment decreased when combining plerixafor with G-CSF, while overall cell viability remained unaffected.
  • Retrospective chart review of 382 patients revealed an odds ratio of 0.08 for achieving individual hematopoietic stem cell collection goals.
  • Supports plerixafor utility in autologous stem cell transplantation, suggesting lower collection success reflects prior exposure to chemotherapy.

Cite This Study

Puzo et al. (2024) studied this question.

synapsesocial.com/papers/68e5932eb6db64358752ebd5https://doi.org/10.1093/labmed/lmae080
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma2009 · 794 citations
  2. 2A Phase II Study of Plerixafor (AMD3100) plus G-CSF for Autologous Hematopoietic Progenitor Cell Mobilization in Patients with Hodgkin Lymphoma2008 · 130 citations
  3. 3Use of Plerixafor for Stem Cell Mobilization in the Setting of Autologous and Allogeneic Stem Cell Transplantations: An Update2021 · 34 citations
  4. 4Impact of Mobilization and Remobilization Strategies on Achieving Sufficient Stem Cell Yields for Autologous Transplantation2008 · 354 citations
  5. 5Long-Term Outcome after Autologous Stem Cell Transplantation with Adequate Peripheral Blood Stem Cell Mobilization Using Plerixafor and G-CSF in Poor Mobilizer Lymphoma and Myeloma Patients2011 · 22 citations