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September 5, 2024Open Access

Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins

Cassandra L Phillips Maryam Faridounnia Rachel A. Battaglia Baggio Evangelista Todd J. Cohen Puneet Opal Thomas W. Bouldin Diane Armao Natasha T. Snider

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Abstract

Giant Axonal Neuropathy (GAN) is a neurodegenerative disease caused by loss-of-function mutations in the

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Cite This Study

Phillips et al. (2024) studied this question.

synapsesocial.com/papers/68e5944ab6db64358752f738 https://doi.org/10.1101/2024.09.03.611033

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Neurofilament accumulation disrupts autophagy in giant axonal neuropathy2024
2Gigaxonin is required for intermediate filament transportOriginal Research · 2022
3Axon guidance genes are regulated by <scp>TDP</scp>‐43 and <scp>RGNEF</scp> through long‐intron removal2024 · 3 citations
4<scp>T2</scp> Hyperintensities in Gracile Tracts of Cervical Spinal Cord in Giant Axonal Neuropathy (<scp>GAN</scp>)2025
5Multiple motor proteins regulate TDP-43 anterograde axonal transportOriginal Research · 2026 · 1 citations