Comprehensive evaluation of the effectiveness of the treatment of chronic recurrent aphthous stomatitis in patients with infectious pathology of the genitourinary system

BACKGROUND: The role of infectious-allergic, neurogenic, occupational, immune, cross-origin etiopathogenesis of chronic recurrent aphthous stomatitis (ChRAS) is substantiated according to literature data, and information is also provided between the relationship of pathology of ChRAS and chronic kidney diseases (ChKD) and viral infection in the oral cavity (OC) against the background of pathologies of the genitourinary system AIM: The aim of the study was to study the effectiveness of complex diagnostics and treatment of ChRAS in patients with infectious pathologies of the genitourinary system. MATERIAL AND METHODS: 120 patients aged from 18 to 70 years suffering from ChRAS were examined; 80 of them (including 40 patients each (main group MG-1 and comparative group CG) on the background of infectious pathology of ChKD. To assess the results of treatment in patients with OG-1 and SG, antihistamine, sedative, immunomodulators, multivitamin preparations were included, for local treatment, the solution "Eludril" on the OC– sanation of OC, rinsing additional local treatment "Ginger" and the plant "Myrrh". The results proved the effectiveness of the proposed methods of treatment. RESULTS: It was found that patients with ChRAS against the background of ChKD were more likely to have regional lymphadenitis, Myculich’s aphtha, swelling of the OC, a high level of intensity of dental caries and unsatisfied periodontal index, while having a longer and more severe course of ChRAS. It is indicated that the main pathogenetic factor of the recurrence of infection in ChRAS is the immunodeficiency of the body and violations of the biochemical composition of the blood. CONCLUSION: Thus, patients with ChRAS and ChKD may develop a chronic inflammatory process associated with the presence in the oral cavity (OC) and opportunistic pathogens as a result of local immunodeficiency, which is largely determined by the location and prevalence of inflammation in the whole body.