Supplementary Figure S6 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma

Xu Zhang; Shoufu Duan; Panagiota E. Apostolou; Xiaoping Wu; Jun Watanabe; Matthew Gallitto; Tara Barron; Kathryn R. Taylor; Pamelyn J. Woo; Xu Hua; Hui Zhou; Hong-Jian Wei; Nicholas McQuillan; Kyung‐Don Kang; Gregory K. Friedman; Peter Canoll; Kenneth Chang; Cheng‐Chia Wu; Rintaro Hashizume; Christopher R. Vakoc; Michelle Monje; Guy M. McKhann; Joseph A. Gogos; Zhiguo Zhang

doi:10.1158/2159-8290.26934942

Key Points

FOSL1 colocalizes directly with the chromatin remodeler CHD2 to regulate pediatric glioma cell viability, establishing a cooperative pathway in tumor cell maintenance.
Experimental analysis of pediatric glioma models demonstrates that CHD2 and FOSL1 jointly modulate downstream gene expression to control essential cellular survival programs.
Highlights potential targets within neuron glioma interactions to disrupt pediatric glioma growth; cell culture model; further preclinical in vivo validation is warranted.

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Implication

Preclinical analysis demonstrates FOSL1 colocalization with CHD2 regulating cell viability in pediatric glioma, suggesting cooperative transcriptional control.

Abstract

FOSL1 colocalizes with CHD2 to regulate cell viability and gene expression.

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Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e59691b6db64358753132f https://doi.org/10.1158/2159-8290.26934942

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Supplementary Figure S6 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S6 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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