Supplementary Figure S3 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma

Xu Zhang; Shoufu Duan; Panagiota E. Apostolou; Xiaoping Wu; Jun Watanabe; Matthew Gallitto; Tara Barron; Kathryn R. Taylor; Pamelyn J. Woo; Xu Hua; Hui Zhou; Hong-Jian Wei; Nicholas McQuillan; Kyung‐Don Kang; Gregory K. Friedman; Peter Canoll; Kenneth Chang; Cheng‐Chia Wu; Rintaro Hashizume; Christopher R. Vakoc; Michelle Monje; Guy M. McKhann; Joseph A. Gogos; Zhiguo Zhang

doi:10.1158/2159-8290.26934951

Key Points

Chromodomain helicase DNA-binding protein 2 selectively binds to gene regulatory elements of axon-guidance and synaptic genes in pediatric glioma cells.
Molecular analysis demonstrates direct genomic occupancy of the CHD2 regulator across defined synaptic loci and developmental axon-guidance sequences.
Preclinical findings suggest that CHD2 regulates neuron glioma interactions, highlighting potential chromatin targets in pediatric glioma biology.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Preclinical analysis reveals CHD2 binding to synaptic and axon-guidance regulatory elements in pediatric glioma, highlighting chromatin control of neuron–glioma interactions.

Abstract

CHD2 binds to the gene regulatory elements of axon-guidance and synaptic genes.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e59691b6db643587531337 https://doi.org/10.1158/2159-8290.26934951

View Full Paper

Ask AI

Bookmark

Share

Supplementary Figure S3 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading