Supplemental Figure 1 from Diet Modulates the Gut Microbiome, Metabolism, and Mammary Gland Inflammation to Influence Breast Cancer Risk

Supplemental Figure 1: Diet regulates fecal microbiota populations. A. Summarized OTU abundances into Bray–Curtis dissimilarities and performed a non-metric multidimensional scaling (NMDS) ordination. There is a strong overall effect of diet on community-level differences between diet types (permutational multivariate analysis of variance: P < 0.001, R-squared = 0.44, n = 5). B. Microbial diversity, measured by the Shannon index, was not significantly affected by diet type. C. OTUs were aggregated into family-level taxa, and the relative abundance of the most abundant microbes was plotted. General linear models were used to test for differences in OTU abundances by examining the overall community alone. After adjusting for P-values (α value threshold = 0.01), we found 106 differentially abundant OTUs.