Figure 3 from Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer

Oncogenic signaling and cell of origin associates with the biclusters. A, Heatmap of distribution of the top 250 most variable PARADIGM concepts across the bicluster switches in the TCGA-BRCA dataset. The term values were obtained from Berger and colleagues (30) pan-cancer analysis and hierarchically clustered. Annotations show proliferation, tumor purity, switch identity (UF and LF of MB_1, MB_2, or MB_3), Pam50, and histology classifications. Transcriptomic signatures based on PARADIGM concepts are shown on the right. B, Association of mammary gland cell states (37) and transcriptomic switches in the METABRIC dataset. Two-dimensional distribution plots of samples by two biclusters are shown overlaid with cell-of-origin marker GSVA values. C, Scheme of signaling of the multistate switch in the MB1 and MB3 biclusters.