Figure 2 from Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer

Metabolic transcriptome switches override PAM50 classification. A–D, Visualization of bicluster switches based on CV values of individual genes in the METABRIC breast cancer dataset analysis in the indicated metabolic pathways. Genes are ranked by the MB1 CV values and directly compare the MB1 and MB2 biclusters on the left side of each panel. The ranked MB3 values are shown on the right side of each panel. E–H, Sub-pathway gene clusters group according to the bicluster switches across PAM50 categories. Bicluster forks samples were grouped according to their intrinsic subtype and the average transcript levels of each gene in the indicated pathways were calculated. Hierarchical clustering of genes and sample groups was performed (Pearson distance and ward2 clustering). Group classifications according to the biclusters and intrinsic breast cancer subtypes are shown on the right.