Figure 5 from Poor Prognosis among Radiation-Associated Bladder Cancer Is Defined by Clinicogenomic Features

Prognostic value of the smoking and XRT signatures in TCGA and proposed scheme of RT-associated bladder cancer development. The Pearson correlation between the UNC signature motif frequency profile and TCGA BLCA samples was calculated, and TCGA samples were split into high and low groups at the median correlation. Samples were further split by CDKN2A status, and KM curves were generated. A multivariate Cox proportional hazard model was calculated for both the (A) smoking signature and (B) XRT signature. For all KM plots, dashed lines indicate median survival. C, Proposed model for the interplay between preexisting alteration in the urothelium and RT. WT, wild type.