Supplementary Figures from Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition

Supplementary Figure S1: Multiplex gene editing of SF3B1 K700E in CD34+ cells. Supplementary Figure S2: Splicing and single cell transcriptome analysis of SF3B1-mutant HSPCs. Supplementary Figure S3: Mis-splicing and expression of BUBR1 and CDC27. Supplementary Figure S4: Drug sensitivity of SF3B1-mutant cells. Supplementary Figure S5: The role of candidate mis-spliced genes in CHK1i sensitivity. Supplementary Figure S6: Prexasertib testing in CB HSPCs, MDS samples, and in vivo.