Experimental Study of the Influence of Adverse External Factors on the Histological Structure of Bone Tissue Components of Rats

Environmental contamination is becoming an increasingly serious problem for humanity every year.One of the most dangerous, long-acting and stable pollutants are heavy metals, the most common man-made associations of which are represented by salts of mercury, cadmium and lead.Cadmium and its compounds enter the body mainly through the respiratory tract (10-40%).In areas with cadmium-contaminated soils, dust is a potentially important source of the toxicant entering the body.The natural content of cadmium in the most important food products is small and is in the range of 0.001 -1.5 mg/kg (the exception is the kidneys of animals: up to 40 mg/kg), but it can be much higher due to anthropogenic pollution.Chronic cadmium intoxication, mediated by the above-mentioned Cdinduced mechanisms of cytotoxicity, can cause the development of asthenovegetative, asthenoneurotic and neurasthenic syndromes with vegetative disorders, cadmium parkinsonism, progressive pneumosclerosis and emphysema of the lungs, gastrointestinal disorders, kidney and liver dysfunction, damage to the testicles, adrenal glands , hypochromic anemia and lesions of bone and cartilage tissue.Currently, the use of succinates (preparations based on succinic acid) is one of the priorities of modern fundamental and practical medicine.Drugs containing succinic acid (metal succinates, mexidol, reamberin, etc.) are drugs of metabotropic type of action, the pharmacotherapeutic effects of which are aimed at restoring biochemical metabolic reactions disrupted by pathological processes.Succinic acid is an intracellular metabolite that is involved in metabolic processes in the body and Журнал «Перспективи та інновації науки» (Серія «Педагогіка», Серія «Психологія», Серія «Медицина») № 8(42) 2024