What does this research mean for the field?

Heavy metals such as Cd, Pb, and Cu pose significant health risks to animals and humans, and their toxicity can be mitigated through various therapeutic agents. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The editorial aims to synthesize findings on the toxicity of metals and drugs, highlighting further research needs.

March 5, 2026Open Access

Correction: Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III

Key Points

The editorial aims to synthesize findings on the toxicity of metals and drugs, highlighting further research needs.
Reviewed 10 manuscripts encompassing 3 reviews and 7 articles on toxicology topics.
Explored heavy metal toxicity mechanisms and therapeutic interventions in animals and humans.
Analyzed exposure effects and health implications related to metals like Cd, Pb, and Cu.
Heavy metals negatively correlate with health indicators, threatening food chains and animal well-being.
Cu chelators and antioxidants show promise in mitigating metal-induced toxicity.
Emerging studies highlight the need for stricter safety measures in industries using toxic solvents.

Abstract

environment pose significant health threats.Our topic encompasses 10 manuscripts, comprising 3 reviews and 7 articles.These manuscripts delve into the toxicology of drugs (ripretinib, sunitinib, monocrotaline, azvudine, and cantharidin), heavy metals (As, Pb, Hg, Cd, and Cu), and other toxic agents (dimethylacetamide) on the kidney, heart, and liver. The therapeutic potential of Cu chelators, small-molecule inhibitors of Cu, Cu ionophores, naringenin, and selenium in mitigating Cu, Pb, and Cd toxicity is also explored. This editorial aims to synthesize key findings on drug and heavy metal toxicity from recent studies and highlight the next research direction. Two reviews and three articles focus on the heavy metal toxicity of Cd, Pb, and Cu, which pollute the food chain and threaten animal health. Excessive intake of all heavy metals beyond the tolerance limit can lead to toxicity. Afzal A (2025) reviewed how heavy metals pollute the food chain and threaten animal health. After ingestion, heavy metals persist in the body for an extended duration, and the nature of exposure determines whether they induce acute or chronic, clinical or subclinical, or subtle toxicities. Liu ZC (2025) reviewed the biological processes involved in copper uptake, transport, excretion, and storage at both the cellular and systemic levels in terms of cuproptosis and heart failure. Chen ZX (2025) showed that concurrent exposure to PS-MPs and Cd aggravated toxic damage to the liver. Activation of carnitine palmitoyltransferase1 could alleviate PS-MPs and Cd-induced lipid accumulation and autophagy pathway blockage, thus reducing liver injury. Shi YN (2025) showed that naringenin (Nar) reduces CdCl2-induced kidney injury through alleviation of oxidative stress, endoplasmic reticulum stress, and autophagy. Liang YF (2025) showed that blood Cd and Pb levels were negatively correlated with handgrip strength. Selenium could mitigate this negative impact, but its effectiveness plateaus beyond 200 μg/L. Timely diagnosis, targeted antidotes, and management strategies can significantly mitigate the impact of heavy metals on livestock health, productivity, and reproductive performance.Dimethylacetamide is used as a solvent in the dye, leather, and acrylic manufacturing industries. Zhang XX (2025) aimed to elucidate the clinical characteristics associated with dimethylacetamide poisoning. Moreover, the incident calls for enhanced safety measures in industries using DMAC and 4,4'-ODA to prevent similar poisoning events.However, further research is warranted to elucidate the mechanisms and optimize clinical management strategies.Although scientific attention has been given to knowledge on adverse drug reactions, and heavy metal toxicity in humans and animals, more work needs to be done in the area of toxicology exposures, risk assessment, and toxicity mechanisms.

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