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July 26, 2026Toxicology and Industrial Health

Molecular mechanisms of heavy metal-induced cancer: Insights from animal models and human implications

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Authors

SDSneha DhanasekaranKDK. V. DHANEESH

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Overview

Review synthesizes evidence on heavy metal carcinogenic mechanisms, highlighting human health risks.

Key Points

  • The review aims to elucidate the molecular mechanisms by which heavy metals induce cancer and their implications for human health.
  • Synthesized evidence from studies examining the effects of heavy metals on cancer development.
  • Discussed toxicodynamics of metal mixtures and their interactions.
  • Evaluated emerging technologies and gut microbiome impact on metal bioavailability.
  • Co-exposure to cadmium and arsenic led to synergistic DNA damage 3–5 times greater than expected.
  • Mitochondrial dysfunction and p53 pathway alterations were significant contributors to carcinogenicity.
  • Metal combinations showed endpoint-specific interaction profiles, increasing neurological and genotoxic risks.

Cite This Study

Dhanasekaran et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78d04https://doi.org/10.1177/07482337261469287
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