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September 2, 2024MoleculesOpen Access

Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2

Han Wee Ong Xuan Yang Jeffery L. Smith Sharon Taft-Benz Stefanie Howell Rebekah J. Dickmander Tammy M. Havener Marcia K. Sanders Jason W. Brown Rafael M. Couñago Edcon Chang Andreas Krämer Nathaniel J. Moorman Mark T. Heise Alison D. Axtman David H. Drewry Timothy M. Willson

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Abstract

The host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in vivo, potent and selective CSNK2 inhibitors with good pharmacokinetic properties are required. Inhibitors based on the pyrazolo[1,5-

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Ong et al. (2024) studied this question.

synapsesocial.com/papers/68e59a26b6db643587534c6e https://doi.org/10.3390/molecules29174158

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Strategic Fluorination to Achieve a Potent, Selective, Metabolically-Stable, and Orally-Bioavailable Inhibitor of CSNK2.2024
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