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September 1, 2024Cell ReportsOpen Access

Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation

Janneke G. C. Peeters Stephanie Silveria Merve Özdemir Srinivas Ramachandran Michel DuPage

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Abstract

The immunosuppressive function of regulatory T (Treg) cells is essential for maintaining immune homeostasis. Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27) methyltransferase, plays a key role in maintaining Treg cell function upon CD28 co-stimulation, and Ezh2 deletion in Treg cells causes autoimmunity. Here, we assess whether increasing H3K27me3 levels, by using an Ezh2

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Cite This Study

Peeters et al. (2024) studied this question.

synapsesocial.com/papers/68e59c4cb6db643587536762 https://doi.org/10.1016/j.celrep.2024.114724

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