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April 10, 2024Open Access

Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation

Janneke G. C. Peeters Stephanie Silveria Merve Özdemir Srinivas Ramachandran Michel DuPage

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Abstract

The immunosuppressive function of regulatory T (Treg) cells is essential for maintaining immune homeostasis. Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27) methyltransferase, plays a key role in maintaining Treg cell function upon CD28 co-stimulation, and

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Cite This Study

Peeters et al. (2024) studied this question.

synapsesocial.com/papers/68e6fa98b6db643587674f4d https://doi.org/10.1101/2024.04.05.588284

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation2024 · 29 citations
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3T cell receptor signaling induces expression of lysine demethylase KDM6B to maintainTreg homeostasis.Original Research · 2026
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5Abstract LB339: Transient EZH2 suppression by tazemetostat during <i>in vitro</i> expansion maintains T cell stemness and improves adoptive T cell therapy2024