Evaluation of Glucose, 8-isoprostane, and Some Reproductive Hormones Levels in Women with Obesity, Type 1 Diabetes and Hyperprolactinemia.

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Comparative study reveals elevated 8-isoprostane and testosterone in women with obesity, indicating reproductive and oxidative impairment.

Blood glucose and HbA1c rise markedly in type 1 diabetes, whereas 8-isoprostane elevates significantly in both obesity and hyperprolactinemia cohorts (P<=0.05).
Assessment of 92 women aged 20 to 40 years across hospital centers compares follicle stimulating hormone, testosterone, and glycemic indices across four cohorts.
Highlights elevated testosterone and 8-isoprostane as indicators of reproductive disruption in obesity, though limited institutional scope warrants broader validation.

Ghali et al. (2024) studied this question.

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Comparative study reveals elevated 8-isoprostane and testosterone in women with obesity, indicating reproductive and oxidative impairment.