Analysis of the results of tuberculosis drug resistance surveillance in Yuexiu District, Guangzhou City, 2013-2022

Introduction: To understand the drug-resistant situation and trend of tuberculosis patients in Yuexiu District, Guangzhou City, from 2013 to 2022, and to provide a scientific basis for the development of rational drug-resistant tuberculosis prevention and control strategies in Guangzhou City.Methods: All patients who were diagnosed with active tuberculosis in Guangzhou Chest Hospital from January 1, 2013 to December 31, 2022 were collected as study subjects, and a total of 5,191 patients were enrolled in the study.The basic conditions and diagnostic and therapeutic information of the study subjects were collected.Sputum specimens were subjected to smear and isolation and culture.Culture-positive strains of bacteria were identified by bacterial groups.A total of 1,659 strains of Mycobacterium tuberculosis (MTB) isolates were obtained.The drug susceptibility test was carried out using the proportionality method on the MTB isolates for nine types of anti-tuberculosis medicines,and comparatively analyzed the resistance of the strains.Results: A total of 1,659 patients with MTB were cultured, 439 were drug-resistant, 255 were monoresistant, 121 were poly-resistant, 62 were multidrug-resistant.The resistance rate was 26.46% (439/1659), the mono-resistance rate was 15.37 % (255/1659), the poly-resistance rate was 7.29% (121/1659), the multidrug resistance rate was 3.74 % (62/1659) .The number (rate) of drug-resistant patients in the primary treatment was 389 [(25.63%).(389/1659)].The number (rate)of drug-resistant patients in retreatment was 50 [ (35.46%) (50/1659)].The number (rate) of multidrug-resistant patients in the primary treatment was 39 (2.57%) [(39/1659)].The number (rate) of multidrug-resistant cases in retreatment patients was 23 [(16.31%)(23/1659)].The resistance rate and multidrug resistance rate of isolates from retreatment patients were higher than primary treatment patients, the differences were statistically significant. Conclusion s:The problem of drug-resistant tuberculosis transmission in Guangzhou needs to be focused on, drug-resistant screening should be further increased to do a good job of controlling the source of infection.chi-square test.The trend of drug resistance over time was analyzed by the chi-square trend test, and the difference was considered statistically significant at P < 0.5.Test level = 0.05.