Effect of 1-Butyl-3-Methylimidazolium Hydroxide [Bmim]OH on the Nephrocytes of Vertebrate Model Mus musculus

By considering the biomedical approach of green chemistry, Ionic Liquids (ILs) were known for their low vapour pressure, making them an environment friendly substitute for conventional solvents. The present investigation enlightens the impact of acute effect of orally administered IL 1-butyl 3-methylimidazolium hydroxide [Bmim]OH against kidney of Mus musculus. Under the experimentation, selected healthy adult animals were administered orally with a predetermined median lethal dose (LD50) for 12hr. and 24 hr. exposure respectively. After completion of the exposure period, the targeted tissue was analyzed for histopathology technique and the level of lipid peroxidation was measured. Exposure-dependent tissue alterations were observed and reported pathophysiological conditions. [Bmim]OH was not significantly affected on kidney of mice. Results obtained were interpreted for excretory mechanism and renal biology in the vertebrate experimental model Mus musculus.