What does this research mean for the field?

Imatinib exerts cardiotoxic effects through a complex pattern of cellular alterations, including necrosis, autophagy, and apoptosis, and the severity of these lesions is exacerbated by high arterial blood pressure. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 21, 2011Toxicologic Pathology

A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat

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Why the study?

Does imatinib induce cardiotoxicity in rat models?

Population

Male spontaneously hypertensive rats (SHRs), Sprague Dawley (SD) rats, and isolated myocytes

Comparison

Imatinib vs Water (vehicle control)

Design

Preclinical

Follow-up

10 to 14 days

Authors

EHEugene H. HermanNational Cancer Institute AKAlan KnaptonUnited States Food and Drug Administration ERElliot T. RosenUnited States Food and Drug Administration

Discussion

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Implication

Imatinib cardiotoxicity in hypertensive rat models should not change practice; leaves open human translation and need for clinical studies.

Structured PICO

Does imatinib induce cardiotoxicity in rat models?

Population

Male spontaneously hypertensive rats (SHRs), Sprague Dawley (SD) rats, and isolated myocytes

Intervention

Imatinib (oral doses of 10, 30, 50, or 100 mg/kg daily for 10 or 14 days; 5 mM for isolated myocytes)

Comparator

Water (vehicle control)

Outcome

Cardiac lesions (cytoplasmic vacuolization and myofibrillar loss)safety

Imatinib exerts complex cardiotoxic effects in rat models, with severity exacerbated by underlying hypertension.

Cite This Study

Herman et al. (2011) studied this question.

synapsesocial.com/papers/6a198a0b124e01de928dfa23 https://doi.org/10.1177/0192623311419524

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Implication

Imatinib cardiotoxicity in hypertensive rat models should not change practice; leaves open human translation and need for clinical studies.

A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider