Brief and diverse excitotoxic insults increase the neuronal nuclear membrane permeability in the neonatal brain, resulting in neuronal dysfunction and cell death.

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca