Host–Guest Interactions Induced Enhancement in Oxidase-Like Activity of a Benzothiadiazole Dye Inside an Aqueous Pd₈L₄ Barrel

The effect of host–guest interactions on the chemistry of encapsulated molecules is a fascinating field of research that has gained momentum in recent years. Much of the work in this field has been focused on the effect of such interactions on catalysis and photoluminescence of encapsulated dyes. However, the effect of such interactions on related photoinduced processes, such as photoregulated oxidase-mimicking activity, has not been explored much. Herein, we report a unique example of enhancement of oxidase-like activity of a benzothiadiazole dye (G1) in water through encapsulation within a M8L4 molecular barrel (1). Favorable host–guest interactions helped the encapsulated guest G1 to have better photoinduced electron transfer to molecular oxygen leading to increased production of superoxide radical anions and oxidase-like activity. Furthermore, encapsulation inside 1 also caused a change in the redox potentials of the guest (G1) which after photoinduced electron transfer produced a better oxidizing agent than free G1. These phenomena combined to enhance the oxidase-like activity of dye G1 upon encapsulation inside cage 1. The present report demonstrates a unique effect of host–guest chemistry on photoregulated processes.