Systemic mastocytosis successfully managed using CytoSorb® during cardiopulmonary bypass for aortic valve replacement

We describe the case of a 72-year-old male with a history of systemic mastocytosis scheduled for on-pump aortic valve replacement for severe aortic insufficiency. Anesthesia and peri-operative management included avoidance of histamine-releasing drugs, methylprednisolone and clemastin prophylaxis. Furthermore, a CytoSorb ® cartridge has been added to the bypass circuit and hemoadsorption was performed throughout the entire cardiopulmonary bypass (CPB) duration. CytoSorb ® is a hemoadsorption device designed to remove various cytokines and drugs from the blood. The use of CytoSorb ® during CPB in our case was not associated with adverse events, and the patient did not present any allergic or anaphylactic reaction.