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August 28, 2024American Journal of Clinical Pathology

Additional reporting of diffuse and homogeneous ROS-1 SP384 immunoreactivity enhances prediction of ROS1 fusion–positive non-small cell lung cancer

Bokyung Ahn Se Jin Jang Hee Sang Hwang

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Abstract

ROS-1 immunohistochemistry (IHC) is a common method for screening ROS1 fusion in the clinical management of non-small cell lung cancer. The interpretation criteria for ROS-1 SP384 IHC, however, remain unestablished.

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Cite This Study

Ahn et al. (2024) studied this question.

synapsesocial.com/papers/68e5aa5eb6db643587544854 https://doi.org/10.1093/ajcp/aqae118

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Assessment of ros1 gene rearrangement in non-small cell lung cancer: concordance between ros1 sp384 immunohistochemistry and ros1 fish assay in a single center in tÃƒÂ¼rkiyeOriginal Research · 2025
2Detection of ROS1 Gene Rearrangement in Lung Adenocarcinoma: Comparison of IHC, FISH and Real-Time RT-PCRDiagnostic Study · 2015 · 103 citations
3Novel Pattern of Nuclear Staining With ROS1 Immunohistochemistry: A Case ReportCase Report · 2026
4Identifying and Targeting <i>ROS1</i> Gene Fusions in Non–Small Cell Lung CancerOriginal Research · 2012 · 464 citations
5C77-23 Prognostic Value of Ros1 Fusion in Lung Adenocarcinoma Stratified by Clinicopathologic and Radiological FeaturesCohort Study · 2026

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Abstract 5714: Amplicon-based DNA and RNA co-detection improves ROS1 fusion identification across Chinese solid tumors compared with hybrid capture DNA-NGS2026
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ROS1-positive non-small cell lung cancer: from genomics to treatment decisions2026

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