Mutual Amplification of GLI2/Hedgehog and Transcription Factor JUN/AP‐1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies

Christina Bergmann; Sara Chenguiti Fakhouri; Trinh‐Minh Thuong; Tim Filla; Aleix Rius Rigau; Arif B. Ekici; Benita Merlevede; Ludwig Hallenberger; Honglin Zhu; Clara Dees; Alexandru‐Emil Matei; Janina Auth; Andrea‐Hermina Györfi; Xiang Zhou; Simon Rauber; Aline Bözec; Nicholas Dickel; Chunguang Liang; Meik Kunz; Georg Schett; Jörg H. W. Distler

doi:10.1002/art.42979

Abstract

Deregulation of the cJUN/AP-1 and hedgehog/GLI2 signaling pathways has been implicated in fibroblast activation in systemic sclerosis (SSc). However, the consequences of their concomitant up-regulation are unknown. Here, we tested the hypothesis that mutual amplification of both pathways might drive persistent fibroblast activation.

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Bergmann et al. (2024) studied this question.

synapsesocial.com/papers/68e5aa67b6db643587544d4d https://doi.org/10.1002/art.42979

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Mutual Amplification of GLI2/Hedgehog and Transcription Factor JUN/AP‐1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies

Abstract

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Cite This Study

Mutual Amplification of GLI2/Hedgehog and Transcription Factor JUN/AP‐1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies

Abstract

Discussion

Cite This Study

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