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August 27, 2024mSphereOpen Access

Identification and characterization of archaeal-type FAD synthase as a novel tractable drug target from the parasitic protozoa Entamoeba histolytica

Dewi Wulansari Ghulam Jeelani Euki Yazaki Tomoyoshi Nozaki

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Abstract

Flavin adenine dinucleotide (FAD) is an essential cofactor for numerous flavoenzymes present in all living organisms. The biosynthesis of FAD from riboflavin involves two sequential reactions catalyzed by riboflavin kinase and flavin adenine dinucleotide synthase (FADS).

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Wulansari et al. (2024) studied this question.

synapsesocial.com/papers/68e5ac8db6db643587546318 https://doi.org/10.1128/msphere.00347-24

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