Development of the Technology of Procurement of “Ginkrosmelan” Microcapsules from Natural Origin Materials and Assessment of Quality Criteria

In modern times, great prospects in the field of drug therapy are related to the effect of medicinal substances on organs, tissues or cells.In this regard, microencapsulated medicinal substances (microcapsules, microspheres, nanocapsules) have proven themselves to be due to intravenous injection into certain organs and tissues.Taking into account the mentioned perspective, for the first time, for the treatment of atherosclerosis, an extract was obtained from a phyto composition developed in the ratio of 5:5:5:5 from ginkgo biloba, rose hips, lemon balm and fragrant dill plants.Based on this extract, the composition (phyto substance, aerosil, beeswax, hexane) and technology of miro capsules, which we conventionally call "Ginkrosmelan", were developed.Preparation of microcapsules was performed by physical method.Some technological properties of the developed microcapsules (size-5,20±0,1μm; moisture absorption 1,23±0,04%; fluidity-2,5±0,11g/sec; scattering mass-1,78±0,04g/cm3) and shelf life (5 years is stable) was studied.Quantification of flavonoids in microcapsules according to rutin was checked by spectrophotometric method and found to be 1.67%.During in vitro studies, the rate of release of biologically active substances from the microcapsules with the optimal composition was studied, and it was determined that the maximum release occurs within 7 hours and is 93.17±0.66%.