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August 26, 2024The Journal of Clinical Endocrinology & MetabolismOpen Access

BRAF-induced EHF expression affects TERT in aggressive papillary thyroid cancer

Yiyi Xu Jiwei Gao Na Wang Jan Zedenius Inga‐Lena Nilsson Weng‐Onn Lui Dawei Xu C. Christofer Juhlin Catharina Larsson Ninni Mu

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Abstract

BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma (PTC) have a synergistic effect on prognosis. This effect is believed to arise from MAPK activation triggered by BRAFV600E, leading to the upregulation of ETS transcription factors that bind to the mutant TERT promoter.

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Xu et al. (2024) studied this question.

synapsesocial.com/papers/68e5adceb6db64358754780c https://doi.org/10.1210/clinem/dgae589

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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