Determination of Aspirin by Resonance Rayleigh Scattering (RRS) Using a Magnetic Molecularly Imprinted Poly(Methacrylic Acid) Probe

Nanosurface-imprinted polymer nanoprobes (Fe3O4@MIP) were prepared by microwave synthesis using Fe3O4 as a nanosubstrate, aspirin as a template, α-methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator. Characterization of Fe3O4@MIP revealed that the spectral probe exhibited strong resonance Rayleigh scattering (RRS) for aspirin. With the increase in aspirin concentration, the RRS energy transfer (RRS-ET) was enhanced, and the signal at 370 nm decreased, providing a linear range from 0.25 to 12.5 μmol/L and a detection limit (DL) of 0.08 μmol/L. The developed protocol was used for the determination of aspirin in drugs with recoveries from 93.2 to 102.6.